Diocalm Ultra Capsules

1. Name Of The Medicinal Product

Diocalm Ultra Capsules.

2. Qualitative And Quantitative Composition

Loperamide Hydrochloride Ph Eur 2.0mg / capsule.

3. Pharmaceutical Form

Capsule.

4. Clinical Particulars

4.1 Therapeutic Indications

For the symptomatic treatment of acute diarrhoea.

4.2 Posology And Method Of Administration

Oral. Adults and children aged 12 years and over:

P classification: Two capsules immediately, followed by one capsule after each further bout of diarrhoea up to a maximum of eight capsules in any 24 hours.

GSL classification: Two capsules immediately, followed by one capsule after each further bout of diarrhoea up to a maximum of six capsules in any 24 hours.

Not to be given to children under 12 years.

4.3 Contraindications

Hypersensitivity to the active ingredient. Conditions where inhibition of peristalsis is to be avoided, e.g. diverticular disease and ulcerative colitis.

4.4 Special Warnings And Precautions For Use

This product should be used with caution in cases of impaired liver function.

GSL Classification: Patients suffering Irritable Bowel Syndrome should not use this product. The first line of treatment in acute diarrhoea is the prevention or treatment of fluid and electrolyte depletion; this is of particular importance to frail and elderly patients.

The following will appear on the product labeling (P or GSL): Warning: do not exceed the stated dose. Keep out of reach of children. If symptoms persist for more than 24 hours consult your doctor. If you are pregnant, consult your doctor before use. This medicine is for the relief of the symptoms of diarrhoea and is not a substitute for oral rehydration therapy.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

None stated.

4.6 Pregnancy And Lactation

No teratogenic effects have been shown in animals. However safety in humans has not been established and the product should only be taken under medical supervision. Caution is advised during lactation.

4.7 Effects On Ability To Drive And Use Machines

None stated.

4.8 Undesirable Effects

Rarely, skin rashes, including urticaria, have been reported.

4.9 Overdose

The following effects may be observed in cases of overdose: constipation, ileus and neurological symptoms. Treatment would be symptomatic. In severe overdose, naloxone can be given as an antidote if required.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

By binding to opiate receptors in the gut wall, loperamide hydrochloride reduces propulsive peristalsis, increases intestinal transit time and enhances resorption of water and electrolytes.

5.2 Pharmacokinetic Properties

Following partial absorption in the gastrointestinal tract, loperamide undergoes first-pass metabolism in the liver and is excreted predominantly in the faeces. The elimination half-life is reported as about ten hours.

5.3 Preclinical Safety Data

Not applicable.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Lactose (DMV), Maize Starch (Dried), Microcrystalline Cellulose (Avicel PH101), Pregelatinised Starch (Dried), Croscarmellose Sodium, Dimeticone. Shell cap: Yellow Iron Oxide (E172), Black Iron Oxide (E172), Indigo Carmine (E132), Titanium Dioxide (E171), Gelatin. Shell body: Titanium Dioxide (E171), Gelatin.

6.2 Incompatibilities

None stated.

6.3 Shelf Life

36 months unopened.

6.4 Special Precautions For Storage

None.

6.5 Nature And Contents Of Container

Clear blisters of hard polyvinylchloride 250µm thick backed with aluminium foil 0.02 hard silver, smooth shiny-sided hot sealable against PVC and PVdC dull sided unprinted. 6 or 12 capsules per strip are packed in a cardboard carton.

6.6 Special Precautions For Disposal And Other Handling

Not applicable.

7. Marketing Authorisation Holder

SSL International PLC. Venus, 1 Old Park Lane, Trafford Park, Manchester, M41 7HA.

8. Marketing Authorisation Number(S)

PL 17905/0049

9. Date Of First Authorisation/Renewal Of The Authorisation

23/03/06

10. Date Of Revision Of The Text

23/03/06

Flagyl I.V. RTU Intravenous

Generic Name: metronidazole (Intravenous route)

met-roe-NYE-da-zole

Intravenous route(Solution)

Metronidazole has been shown to be carcinogenic in mice and rats. Its use, therefore, should be reserved only for conditions for which it is approved .

Commonly used brand name(s)

In the U.S.

• Flagyl I.V.


• Flagyl I.V. RTU

Available Dosage Forms:

• Solution


• Powder for Solution

Therapeutic Class: Antibiotic

Chemical Class: Nitroimidazole

Uses For Flagyl I.V. RTU

Metronidazole injection is used to treat serious bacterial infections in different areas of the body. It is also used to prevent infections in the intestines before and after surgery for some patients.

Metronidazole belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is to be administered only by or under the immediate supervision of your doctor.

Before Using Flagyl I.V. RTU

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of metronidazole injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of metronidazole injection in geriatric patients.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Amprenavir


• Disulfiram

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amiodarone


• Busulfan


• Fluorouracil


• Mycophenolate Mofetil


• Warfarin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Carbamazepine


• Cholestyramine


• Cyclosporine


• Lithium


• Milk Thistle


• Tacrolimus

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is not recommended. Your doctor may decide not to treat you with this medication, change some of the other medicines you take, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Edema (too much fluid in the body) or


• Leukopenia (low white blood cells), history of or


• Optic neuropathy (eye disease with vision changes), history of or


• Oral thrush (Candida infection) or


• Peripheral neuropathy (nerve disease with pain, numbness, or tingling), history of or


• Seizures, history of or


• Vaginal yeast infection (Candida infection)—Use with caution. May make these conditions worse.

• Liver disease, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of metronidazole

This section provides information on the proper use of a number of products that contain metronidazole. It may not be specific to Flagyl I.V. RTU. Please read with care.

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins.

Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

If you have taken a medicine called disulfiram (Antabuse®) within the last 2 weeks, you should not receive metronidazole until you talk to your doctor. Disulfiram is used to help people who have a drinking problem. If these 2 medicines are used close together, serious unwanted effects may occur.

Precautions While Using Flagyl I.V. RTU

It is important that your doctor check your progress while you are receiving this medicine. This is to make sure that the infection is cleared up. Blood tests may be needed to check for unwanted effects.

Drinking alcoholic beverages while you are receiving this medicine may cause stomach pain, nausea, vomiting, headache, or flushing or redness of the face. Other alcohol-containing preparations (e.g., elixirs, cough syrups, tonics) may also cause problems. This medicine may also cause alcoholic beverages to taste different. You should not drink alcoholic beverages or take other alcohol-containing preparations while you are receiving this medicine.

Check with your doctor right away if you have dizziness, problems with muscle control or coordination, shakiness or an unsteady walk, slurred speech, or trouble with speaking. These may be symptoms of a serious brain condition called encephalopathy.

Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral neuropathy.

Call your doctor right away if you have confusion, drowsiness, fever, a general feeling of illness, a headache, loss of appetite, nausea, a stiff neck or back, or vomiting. These could be symptoms of a serious condition called aseptic meningitis.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Flagyl I.V. RTU Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Agitation


• back pain


• blindness


• blurred vision


• burning, numbness, tingling, or painful sensations in the hands or feet


• confusion


• decreased vision


• dizziness


• drowsiness


• eye pain


• fever


• hallucinations


• headache


• irritability


• mood or mental changes


• nausea


• seizures (convulsions)


• stiff neck or back


• unsteadiness or awkwardness


• unusual tiredness or weakness


• vomiting


• weakness in the arms, hands, legs, or feet

Incidence not known

• Black, tarry stools


• blistering, peeling, or loosening of the skin


• changes in speech patterns


• changes in skin color


• chest pain


• chills


• cough


• diarrhea


• fainting


• feeling of warmth


• itching


• joint or muscle pain


• lower back or side pain


• pain, tenderness, or swelling of the foot or leg


• painful or difficult urination


• pale skin


• red skin lesions, often with a purple center


• red, irritated eyes


• redness of the face, neck, arms, and occasionally, upper chest


• shakiness and unsteady walk


• shortness of breath


• slurred speech


• sore throat


• sores, ulcers, or white spots in the mouth or on the lips


• trouble with speaking


• ulcers, sores, or white spots in the mouth


• unsteadiness, trembling, or other problems with muscle control or coordination


• unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Abdominal or stomach discomfort


• dry mouth


• hives or welts


• redness of the skin


• skin rash


• stuffy nose


• unpleasant metallic taste

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Flagyl I.V. RTU Intravenous resources

• Flagyl I.V. RTU Intravenous Use in Pregnancy & Breastfeeding
• Drug Images
• Flagyl I.V. RTU Intravenous Drug Interactions
• Flagyl I.V. RTU Intravenous Support Group
• 107 Reviews for Flagyl I.V. RTU Intravenous - Add your own review/rating

Compare Flagyl I.V. RTU Intravenous with other medications

• Amebiasis
• Aspiration Pneumonia
• Bacteremia
• Bacterial Infection
• Bacterial Vaginitis
• Bone infection
• Clostridial Infection
• Crohn's Disease, Acute
• Crohn's Disease, Maintenance
• Deep Neck Infection
• Dental Abscess
• Diverticulitis
• Dracunculiasis
• Endocarditis
• Giardiasis
• Helicobacter Pylori Infection
• Intraabdominal Infection
• Joint Infection
• Meningitis
• Pelvic Inflammatory Disease
• Peritonitis
• Pneumonia
• Pseudomembranous Colitis
• Skin Infection
• Surgical Prophylaxis
• Trichomoniasis

Eurax Cream

Pronunciation: kroe-TAM-ih-ton
Generic Name: Crotamiton
Brand Name: Eurax

Eurax Cream is used for:

Treating scabies and relieving itching.

Eurax Cream is a scabicidal antipruritic. Exactly how it works is unknown.

Do NOT use Eurax Cream if:

• you are allergic to any ingredient in Eurax Cream


• you develop severe irritation after applying Eurax Cream


• you experience irritation when applying topical medicines

Contact your doctor or health care provider right away if any of these apply to you.

Before using Eurax Cream:

Some medical conditions may interact with Eurax Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have irritated, inflamed, raw, or weeping skin

Some MEDICINES MAY INTERACT with Eurax Cream. However, no specific interactions with Eurax Cream are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Eurax Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Eurax Cream:

Use Eurax Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Before using Eurax Cream, bathe and dry your skin completely.


• For scabies - Apply enough medicine to cover the entire body from the chin down. Make sure that you apply medicine in all folds and creases of your body, such as between the fingers and toes, under the arms, and to the groin area. Rub the medicine in completely. Apply the medicine a second time after 24 hours has passed, unless directed otherwise by your doctor. Do not bathe before applying the second dose. Change clothing and bed linen the next morning. Clothing and bed linen should be dry-cleaned or washed in the hot cycle of the washing machine. Bathe to remove the medicine 48 hours after the second dose.


• For itching - Rub medicine gently into the affected areas until it is completely rubbed in. Wash hands after use unless your hands are part of the treated area.


• If you miss a dose of Eurax Cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Eurax Cream.

Important safety information:

• Do not use Eurax Cream on inflamed, raw, or weeping skin.


• Itching may continue for up to several weeks due to sensitivity to mites. This does not indicate treatment failure. Contact your doctor before using Eurax Cream again.


• Eurax Cream may be harmful if swallowed. If you or someone you know may have taken Eurax Cream by mouth, contact your local poison control center or emergency room immediately.


• Avoid getting Eurax Cream in your eyes, nose, or mouth. If you get Eurax Cream in your eyes, rinse immediately with cool water.


• Use Eurax Cream with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Eurax Cream during pregnancy. It is unknown if Eurax Cream is excreted in breast milk. If you are or will be breast-feeding while you are using Eurax Cream, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Eurax Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Irritated skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe irritation.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Eurax side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include burning or irritation of the mouth or throat, nausea, vomiting, and abdominal pain.

Proper storage of Eurax Cream:

Store Eurax Cream at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep Eurax Cream out of the reach of children and away from pets.

General information:

• If you have any questions about Eurax Cream, please talk with your doctor, pharmacist, or other health care provider.


• Eurax Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Eurax Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Eurax resources

• Eurax Side Effects (in more detail)
• Eurax Use in Pregnancy & Breastfeeding
• Eurax Support Group
• 0 Reviews for Eurax - Add your own review/rating

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• Pruritus
• Scabies

gentamicin ophthalmic

Generic Name: gentamicin ophthalmic (JEN ta MYE sin off THAL mik)

Brand names: Garamycin Ophthalmic, Gentak, Gentasol, Ocu-Mycin, Genoptic, Gentacidin

What is gentamicin ophthalmic?

Gentamicin ophthalmic is an antibiotic.

Gentamicin ophthalmic is used to treat bacterial infections of the eyes.

Gentamicin ophthalmic may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about gentamicin ophthalmic?

Do not touch the dropper or tube opening to any surface, including your eyes or hands. The dropper or tube opening is sterile. If it becomes contaminated, it could cause an infection in your eye.

Apply light pressure to the inside corner of your eye (near your nose) after each drop to prevent the fluid from draining down your tear ducts.

Who should not use gentamicin ophthalmic?

Do not use gentamicin ophthalmic if you have a viral or fungal infection in your eye. It is used to treat infections caused by bacteria only. It is not known whether gentamicin ophthalmic will harm an unborn baby. Do not use gentamicin ophthalmic without first talking to your doctor if you are pregnant. It is also not known whether gentamicin ophthalmic passes into breast milk. Do not use gentamicin ophthalmic without first talking to your doctor if you are breast-feeding a baby.

How should I use gentamicin ophthalmic?

Use gentamicin ophthalmic eyedrops or ointment exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before using the eyedrops or ointment.

To apply the eyedrops:

• 
  

  Shake the drops gently to be sure the medicine is well mixed. Tilt your head back slightly and pull down on your lower eyelid. Position the dropper above your eye. Look up and away from the dropper. Squeeze out a drop and close your eye. Apply gentle pressure to the inside corner of your eye (near your nose) for about 1 minute to prevent the liquid from draining down your tear duct. If you are using more than one drop in the same eye or drops in both eyes, repeat the process with about 5 minutes between drops.

  
  

To apply the ointment:

• 
  

  Hold the tube in your hand for a few minutes to warm it up so that the ointment comes out easily. Tilt your head back slightly and pull down gently on your lower eyelid. Apply a thin film of the ointment into your lower eyelid. Close your eye and roll your eyeball around in all directions for 1 to 2 minutes. If you are applying another eye medication, allow at least 10 minutes before the next application.

  
  

Do not touch the dropper or tube opening to any surface, including your eyes or hands. The dropper or tube opening is sterile. If it becomes contaminated, it could cause an infection in your eye. Do not use any eyedrop that is discolored or has particles in it. Store gentamicin ophthalmic at room temperature away from moisture and heat. Keep the bottle or tube properly capped.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and use the next one as directed. Do not use a double dose of this medication.

What happens if I overdose?

An overdose of this medication is unlikely to occur. If you do suspect an overdose, wash the eye with water and call an emergency room or poison control center near you. If the drops or ointment have been ingested, drink plenty of fluid and call an emergency center for advice.

What should I avoid while using gentamicin ophthalmic?

Use caution when driving, operating machinery, or performing other hazardous activities. Gentamicin ophthalmic may cause blurred vision. If you experience blurred vision, avoid these activities.

If you wear contact lenses, ask your doctor if you should wear them during treatment. After applying this medication, wait at least 15 minutes before inserting contact lenses, unless otherwise directed by your doctor.

Do not use other eye drops or medications during treatment with gentamicin ophthalmic unless otherwise directed by your doctor.

Gentamicin ophthalmic side effects

Serious side effects are not expected to occur during treatment with this medication.

Commonly, some eye burning, stinging, irritation, itching, redness, blurred vision, eyelid itching, eyelid swelling, or sensitivity to light may occur.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect gentamicin ophthalmic?

Do not use other eye drops or medications during treatment with gentamicin ophthalmic unless otherwise directed by your doctor.

Drugs other than those listed here may also interact with gentamicin ophthalmic. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More gentamicin ophthalmic resources

• Gentamicin ophthalmic Use in Pregnancy & Breastfeeding
• Gentamicin ophthalmic Support Group
• 0 Reviews for Gentamicin - Add your own review/rating

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• Genoptic Advanced Consumer (Micromedex) - Includes Dosage Information


• Gentak Prescribing Information (FDA)


• Gentak eent Monograph (AHFS DI)


• Gentak Cream MedFacts Consumer Leaflet (Wolters Kluwer)

Compare gentamicin ophthalmic with other medications

• Conjunctivitis, Bacterial

Where can I get more information?

• Your pharmacist has additional information about gentamicin ophthalmic written for health professionals that you may read.

Perindopril

Pronunciation: per-IN-doe-prill
Generic Name: Perindopril
Brand Name: Aceon

This drug may cause injury or death to the fetus if used during pregnancy. If you think you may be pregnant, contact your doctor right away.

Perindopril is used for:

Treating high blood pressure. It may be used alone or along with other medicines. It is also used to reduce the risk of heart attack or death caused by heart problems in patients with stable coronary artery disease. It may also be used to treat other conditions as determined by your doctor.

Perindopril is an angiotensin-converting enzyme (ACE) inhibitor. It works by relaxing blood vessels. This helps to lower blood pressure.

Do NOT use Perindopril if:

• you are allergic to any ingredient in Perindopril


• you are pregnant


• you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness), including angioedema caused by treatment with an ACE inhibitor (eg, lisinopril)


• you have severe kidney problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Perindopril:

Some medical conditions may interact with Perindopril. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you are able to become pregnant


• if you have a history of heart problems (eg, heart failure), blood vessel problems (eg, brain or heart blood vessels), bone marrow problems, liver problems, or kidney problems (eg, renal artery stenosis)


• if you have a history of a stroke or kidney transplant


• if you have an autoimmune disease (eg, lupus, scleroderma)


• if you are dehydrated or have low blood volume


• if you have high blood potassium levels, low blood sodium levels, or are on a low-salt (sodium) diet


• if you have diabetes, especially if you are also taking aliskiren


• if you are on dialysis or are scheduled to have surgery

Some MEDICINES MAY INTERACT with Perindopril. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aldosterone blockers (eg, eplerenone), aliskiren, cyclosporine, potassium-sparing diuretics (eg, spironolactone, triamterene), potassium supplements, or trimethoprim because the risk of high blood potassium levels may be increased


• Angiotensin receptor blockers (eg, valsartan) because the risk of serious kidney problems and high blood potassium levels may be increased


• Gold-containing medicines (eg, auranofin) because flushing, nausea, vomiting, and low blood pressure may occur


• Dextran sulfate, diuretics (eg, furosemide, hydrochlorothiazide), or mTOR inhibitors (eg, everolimus) because they may increase the risk of Perindopril's side effects


• Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin) or salicylates (eg, aspirin) because they may decrease Perindopril's effectiveness


• Lithium or sulfonylureas (eg, glyburide) because the risk of their side effects may be increased by Perindopril

This may not be a complete list of all interactions that may occur. Ask your health care provider if Perindopril may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Perindopril:

Use Perindopril as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Perindopril by mouth with or without food.


• Take Perindopril on a regular schedule to get the most benefit from it.


• Taking Perindopril at the same time(s) each day will help you to remember to take it.


• Continue taking Perindopril even if you feel well. Do not miss any doses.


• If you miss a dose of Perindopril, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Perindopril.

Important safety information:

• Perindopril may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Perindopril with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Perindopril may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Avoid sudden changes in posture.


• Drink plenty of fluids while taking Perindopril and avoid engaging in activities that cause excessive sweating. Dehydration, excessive sweating, vomiting, or diarrhea may increase the risk of low blood pressure. Contact your health care provider at once if any of these occur.


• A persistent, unproductive cough may occur. Tell your doctor if this occurs. If caused by Perindopril, this type of cough generally recovers after Perindopril is stopped.


• Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.


• Perindopril may cause a serious side effect called angioedema. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness.


• Perindopril may not work as well in black patients. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse.


• Tell your doctor or dentist that you take Perindopril before you receive any medical or dental care, emergency care, or surgery.


• Rarely, Perindopril may lower the ability of your body to fight infection. This risk may be greater if you have certain other health problems (eg, kidney problems, collagen vascular disease). Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.


• Check with your doctor before you use a salt substitute or a product that has potassium in it.


• If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.


• Lab tests, including liver function, kidney function, blood pressure, and blood electrolyte levels, may be performed while you use Perindopril. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Perindopril with caution in the ELDERLY; they may be more sensitive to its effects, especially dizziness and rash.


• Perindopril should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Perindopril may cause birth defects/fetal and newborn death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if Perindopril is found in breast milk. If you are or will be breast-feeding while you use Perindopril, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Perindopril:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Arm or leg pain; back pain; cough; diarrhea; dizziness; headache; runny nose; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, eyes, throat, or tongue; hoarseness); chest pain; confusion; decreased, difficult, or painful urination; depression; difficulty swallowing; fast, slow, or irregular heartbeat; fever, chills, or sore throat; numbness of an arm or leg; one-sided weakness; prolonged or severe nausea, vomiting, or diarrhea; stomach pain (with or without nausea or vomiting); sudden, severe headache; swelling of the hands, legs, or trunk; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, yellowing of the skin or eyes); symptoms of low blood pressure (eg, fainting, severe dizziness, lightheadedness); unusual tiredness or weakness; vision or speech problems.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Perindopril side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; severe dizziness or lightheadedness; weakness.

Proper storage of Perindopril:

Store Perindopril at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, light, and moisture. Keep Perindopril out of the reach of children and away from pets.

General information:

• If you have any questions about Perindopril, please talk with your doctor, pharmacist, or other health care provider.


• Perindopril is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Perindopril. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Perindopril resources

• Perindopril Side Effects (in more detail)
• Perindopril Use in Pregnancy & Breastfeeding
• Drug Images
• Perindopril Drug Interactions
• Perindopril Support Group
• 1 Review for Perindopril - Add your own review/rating

• Perindopril Prescribing Information (FDA)


• perindopril Advanced Consumer (Micromedex) - Includes Dosage Information


• Aceon Prescribing Information (FDA)


• Aceon Monograph (AHFS DI)


• Aceon Consumer Overview

Compare Perindopril with other medications

• Coronary Artery Disease
• Diabetic Kidney Disease
• Heart Attack
• Heart Failure
• High Blood Pressure
• Left Ventricular Dysfunction

Inibace Plus

Inibace Plus may be available in the countries listed below.

Ingredient matches for Inibace Plus

Cilazapril

Cilazapril monohydrate (a derivative of Cilazapril) is reported as an ingredient of Inibace Plus in the following countries:

• Italy

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Inibace Plus in the following countries:

• Italy

International Drug Name Search

Fosinopril

Pronunciation: fos-IN-oh-pril
Generic Name: Fosinopril
Brand Name: Monopril

Fosinopril may cause injury or death to the fetus if taken after the third month of pregnancy. If you think you may be pregnant, contact your doctor right away.

Fosinopril is used for:

Treating high blood pressure alone or with other medicines. It is used along with other medicines to manage heart failure. It may also be used for other conditions as determined by your doctor.

Fosinopril is an angiotensin-converting enzyme (ACE) inhibitor. It works by relaxing blood vessels. This helps to lower blood pressure.

Do NOT use Fosinopril if:

• you are allergic to any ingredient in Fosinopril or to other ACE inhibitors (eg, lisinopril)


• you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or unusual hoarseness), including angioedema caused by treatment with an ACE inhibitor


• you are in your second or third trimester of pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

Before using Fosinopril:

Some medical conditions may interact with Fosinopril. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you are able to become pregnant


• if you have a history of heart problems (eg, heart failure, aortic stenosis), blood vessel problems, blood flow problems, bone marrow problems, or kidney or liver problems


• if you have a history of stroke, recent heart attack, or kidney transplant


• if you have an autoimmune disease (eg, rheumatoid arthritis, lupus, scleroderma)


• if you are dehydrated or have low blood volume


• if you have high blood potassium levels, low blood sodium levels, or are on a low-salt (sodium) diet


• if you have diabetes, especially if you are also taking aliskiren


• if you are receiving treatments to reduce sensitivity to bee or wasp stings


• if you are having dialysis or apheresis, or are scheduled to have major surgery

Some MEDICINES MAY INTERACT with Fosinopril. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood pressure may be increased


• Aldosterone blockers (eg, eplerenone), aliskiren, potassium-sparing diuretics (eg, spironolactone, triamterene), or potassium supplements because the risk of high blood potassium levels may be increased


• Angiotensin receptor blockers (eg, losartan) or trimethoprim because the risk of serious kidney problems and high blood potassium levels may be increased


• Insulin, sulfonylureas (eg, glipizide), or other oral diabetes medicines (eg, metformin) because the risk of low blood sugar may be increased


• Gold-containing medicines (eg, auranofin) because flushing, nausea, vomiting, and low blood pressure may occur


• Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin) because they may decrease Fosinopril's effectiveness


• Lithium because the risk of its side effects may be increased by Fosinopril

This may not be a complete list of all interactions that may occur. Ask your health care provider if Fosinopril may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Fosinopril:

Use Fosinopril as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Fosinopril by mouth with or without food.


• Do not take an antacid that has aluminum, magnesium, or simethicone in it within 2 hours before or 2 hours after you take Fosinopril.


• Use Fosinopril on a regular schedule to get the most benefit from it. Taking Fosinopril at the same time each day will help you remember to take it.


• Continue to use Fosinopril even if you feel well. Do not miss any doses.


• If you miss a dose of Fosinopril, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Fosinopril.

Important safety information:

• Fosinopril may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Fosinopril with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Fosinopril may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Fosinopril may cause a serious side effect called angioedema. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or unusual hoarseness.


• Fosinopril may not work as well in black patients. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse.


• Dehydration, excessive sweating, vomiting, or diarrhea may increase the risk of low blood pressure. Contact your health care provider at once if any of these occur.


• Check with your doctor before you use a salt substitute or a product that has potassium in it.


• Tell your doctor or dentist that you take Fosinopril before you receive any medical or dental care, emergency care, or surgery.


• Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.


• If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.


• Diabetes patients - Fosinopril may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Fosinopril may interfere with certain lab tests, including certain tests for digoxin blood level. Be sure your doctor and lab personnel know you are taking Fosinopril.


• Lab tests, including blood pressure, blood electrolyte levels, heart function, or kidney or liver function, may be performed while you use Fosinopril. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Fosinopril with caution in the ELDERLY; they may be more sensitive to its effects.


• Fosinopril should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.


• Fosinopril should be used with extreme caution in CHILDREN weighing less than 110 pounds; safety and effectiveness in these children have not been confirmed.


• PREGNANCY AND BREAST-FEEDING: Fosinopril may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Fosinopril is found in breast milk. Do not breast-feed while taking Fosinopril.

Possible side effects of Fosinopril:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; dizziness; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the hands, eyes, mouth, face, lips, or tongue; unusual hoarseness); chest pain; confusion; dark urine; decreased urination; difficulty swallowing; fast, slow, or irregular heartbeat; mental or mood changes; muscle pain or cramping; numbness of an arm or leg; one-sided weakness; slurred speech; stomach pain (with or without nausea or vomiting); symptoms of infection (eg, fever, chills, persistent sore throat); symptoms of low blood pressure (eg, fainting, severe dizziness, lightheadedness); vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Fosinopril side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; severe dizziness or lightheadedness; weakness.

Proper storage of Fosinopril:

Store Fosinopril at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Fosinopril out of the reach of children and away from pets.

General information:

• If you have any questions about Fosinopril, please talk with your doctor, pharmacist, or other health care provider.


• Fosinopril is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Fosinopril. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Fosinopril resources

• Fosinopril Side Effects (in more detail)
• Fosinopril Use in Pregnancy & Breastfeeding
• Drug Images
• Fosinopril Drug Interactions
• Fosinopril Support Group
• 2 Reviews for Fosinopril - Add your own review/rating

• Fosinopril Prescribing Information (FDA)


• fosinopril Advanced Consumer (Micromedex) - Includes Dosage Information


• Fosinopril Sodium Monograph (AHFS DI)


• Monopril Prescribing Information (FDA)


• Monopril Consumer Overview

Compare Fosinopril with other medications

• Diabetic Kidney Disease
• High Blood Pressure
• Left Ventricular Dysfunction